Alpha and beta cell evaluation in patients with thalassaemia intermedia and iron overload.
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چکیده
منابع مشابه
Alpha and beta cell evaluation in patients with thalassaemia intermedia and iron overload.
Insulin and glucagon secretion were studied during an oral glucose tolerance test and arginine infusion in 11 patients with thalassaemia intermedia, who showed laboratory evidence of iron overload. Mean blood glucose concentrations in patients with thalassaemia intermedia were significantly higher than normal and 3 of 11 patients had impaired glucose tolerance. The principal abnormality appears...
متن کاملIron overload in Beta thalassaemia major and intermedia patients.
ABSTRACT BACKGROUND In beta thalassaemia major multiple blood transfusions, ineffective erythropoiesis and increased gastrointestinal iron absorption lead to iron overload in the body. Iron overload impairs the immune system, placing patients at greater risk of infection and illness. Iron overload can be determined by serum ferritin measurement. OBJECTIVE The aim of the present study is to...
متن کاملEffect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia.
INTRODUCTION Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia. MATERIALS AND METHODS We ordered following tests for consideration endocrine abnormalities: fasting plasma glucos...
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Iron deposition in the respiratory system has been proposed as a potential cause of the ventilatory restrictive impairment seen in patients with thalassaemia major (TM) and iron overload. In this study, magnetic resonance imaging (MRI) measurements of the liver (T2 relaxation time) were used as a surrogate index of total body iron burden and the extent to which these measurements correlated wit...
متن کاملBeta-Thalassaemia Intermedia: Evaluation of Endocrine and Bone Complications
OBJECTIVE Data about endocrine and bone disease in nontransfusion-dependent thalassaemia (NTDT) is scanty. The aim of our study was to evaluate these complications in β-TI adult patients. METHODS We studied retrospectively 70 β-TI patients with mean followup of 20 years. Data recorded included age, gender, haemoglobin and ferritin levels, biochemical and endocrine tests, liver iron concentrat...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1985
ISSN: 0032-5473
DOI: 10.1136/pgmj.61.721.963